AustralieFrV1, Main, Exploration, bibRecord, 006586

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Identifieur interne : 006586 ( Main/Exploration ); précédent : 006585; suivant : 006587

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Auteurs : M. John Chapman [France] ; Henry N. Ginsberg [États-Unis] ; Pierre Amarenco [France] ; Felicita Andreotti [Italie] ; Jan Boren [Suède] ; Alberico L. Catapano [Italie] ; Olivier S. Descamps [Belgique] ; Edward Fisher [États-Unis] ; Petri T. Kovanen [Finlande] ; Jan Albert Kuivenhoven [Pays-Bas] ; Philippe Lesnik [France] ; Luis Masana [Espagne] ; Borge G. Nordestgaard [Danemark] ; Kausik K. Ray [Royaume-Uni] ; Zeljko Reiner [Croatie] ; Marja-Riitta Taskinen [Finlande] ; Lale Tokgözoglu [Turquie] ; Anne Tybjaerg-Hansen [Danemark] ; Gerald F. Watts [Australie]

Source :

European heart journal [ 0195-668X ] ; 2011.

RBID : Pascal:11-0287868

Descripteurs français

Pascal (Inist)
- Dyslipémie, Athérosclérose, Triglycéride, Lipoprotéine HDL, Cholestérol, Homme, Malade, Risque élevé, Pathologie de l'appareil circulatoire, Guidage, Conduite à tenir, Recommandation, Appareil circulatoire, Cardiologie, Lipide, Maladie cardiovasculaire.
Wicri :
- topic : Homme, Recommandation.

English descriptors

KwdEn :
- Atherosclerosis, Cardiology, Cardiovascular disease, Cholesterol, Circulatory system, Clinical management, Dyslipemia, Guidance, High risk, Human, Lipids, Lipoprotein HDL, Patient, Recommendation, Triglyceride.

Abstract

Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high- density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) to advise on therapeutic strategies for management. Current evidence supports a causal association between elevated TRL and their remnants, low HDL-C, and cardiovascular risk. This interpretation is based on mechanistic and genetic studies for TRL and remnants, together with the epidemiological data suggestive of the association for circulating trigtycerides and cardiovascular disease. For HDL, epidemiological, mechanistic, and clinical intervention data are consistent with the view that low HDL-C contributes to elevated cardiovascular risk; genetic evidence is unclear however, potentially reflecting the complexity of HDL metabolism. The Panel believes that therapeutic targeting of elevated triglycerides (>1.7mmol/L or 150mg/dL), a marker of TRL and their remnants, and/or low HDL-C (<1.0 mmol/L or 40 mg/dL) may provide further benefit. The first step should be lifestyle interventions together with consideration of compliance with pharmacotherapy and secondary causes of dyslipidaemia. If inadequately corrected, adding niacin or a fibrate, or intensifying LDL-C lowering therapy may be considered. Treatment decisions regarding statin combination therapy should take into account relevant safety concerns, i.e. the risk of elevation of blood glucose, uric acid or liver enzymes with niacin, and myopathy, increased serum creatinine and cholelithiasis with fibrates. These recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105250

Affiliations:

Australie, Belgique, Croatie, Danemark, Espagne, Finlande, France, Italie, Pays-Bas, Royaume-Uni, Suède, Turquie, États-Unis
Angleterre, Grand Londres, Hollande-Septentrionale, Latium, État de New York, Île-de-France
Amsterdam, Londres, Paris, Rome
Université d'Amsterdam, Université de Londres

Le document en format XML

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<author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name>
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<author><name sortKey="Masana, Luis" sort="Masana, Luis" uniqKey="Masana L" first="Luis" last="Masana">Luis Masana</name>
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</affiliation>
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<author><name sortKey="Nordestgaard, Borge G" sort="Nordestgaard, Borge G" uniqKey="Nordestgaard B" first="Borge G." last="Nordestgaard">Borge G. Nordestgaard</name>
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<author><name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K." last="Ray">Kausik K. Ray</name>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>St George's University of London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Reiner, Zeljko" sort="Reiner, Zeljko" uniqKey="Reiner Z" first="Zeljko" last="Reiner">Zeljko Reiner</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University Hospital Center Zagreb</s1>
<s3>HRV</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Croatie</country>
<wicri:noRegion>University Hospital Center Zagreb</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taskinen, Marja Riitta" sort="Taskinen, Marja Riitta" uniqKey="Taskinen M" first="Marja-Riitta" last="Taskinen">Marja-Riitta Taskinen</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Biomedicum</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Biomedicum</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tokgozoglu, Lale" sort="Tokgozoglu, Lale" uniqKey="Tokgozoglu L" first="Lale" last="Tokgözoglu">Lale Tokgözoglu</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Hacettepe University</s1>
<s2>Ankara</s2>
<s3>TUR</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Turquie</country>
<wicri:noRegion>Hacettepe University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Rigshospitalet, University of Copenhagen</s1>
<s3>DNK</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Rigshospitalet, University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F." last="Watts">Gerald F. Watts</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>University of Western Australia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">European heart journal</title>
<title level="j" type="abbreviated">Eur. heart j.</title>
<idno type="ISSN">0195-668X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">European heart journal</title>
<title level="j" type="abbreviated">Eur. heart j.</title>
<idno type="ISSN">0195-668X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Cholesterol</term>
<term>Circulatory system</term>
<term>Clinical management</term>
<term>Dyslipemia</term>
<term>Guidance</term>
<term>High risk</term>
<term>Human</term>
<term>Lipids</term>
<term>Lipoprotein HDL</term>
<term>Patient</term>
<term>Recommendation</term>
<term>Triglyceride</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dyslipémie</term>
<term>Athérosclérose</term>
<term>Triglycéride</term>
<term>Lipoprotéine HDL</term>
<term>Cholestérol</term>
<term>Homme</term>
<term>Malade</term>
<term>Risque élevé</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Guidage</term>
<term>Conduite à tenir</term>
<term>Recommandation</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Lipide</term>
<term>Maladie cardiovasculaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Recommandation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high- density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) to advise on therapeutic strategies for management. Current evidence supports a causal association between elevated TRL and their remnants, low HDL-C, and cardiovascular risk. This interpretation is based on mechanistic and genetic studies for TRL and remnants, together with the epidemiological data suggestive of the association for circulating trigtycerides and cardiovascular disease. For HDL, epidemiological, mechanistic, and clinical intervention data are consistent with the view that low HDL-C contributes to elevated cardiovascular risk; genetic evidence is unclear however, potentially reflecting the complexity of HDL metabolism. The Panel believes that therapeutic targeting of elevated triglycerides (>1.7mmol/L or 150mg/dL), a marker of TRL and their remnants, and/or low HDL-C (<1.0 mmol/L or 40 mg/dL) may provide further benefit. The first step should be lifestyle interventions together with consideration of compliance with pharmacotherapy and secondary causes of dyslipidaemia. If inadequately corrected, adding niacin or a fibrate, or intensifying LDL-C lowering therapy may be considered. Treatment decisions regarding statin combination therapy should take into account relevant safety concerns, i.e. the risk of elevation of blood glucose, uric acid or liver enzymes with niacin, and myopathy, increased serum creatinine and cholelithiasis with fibrates. These recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Croatie</li>
<li>Danemark</li>
<li>Espagne</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>Turquie</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Latium</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Londres</li>
<li>Paris</li>
<li>Rome</li>
</settlement>
<orgName><li>Université d'Amsterdam</li>
<li>Université de Londres</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M. John" last="Chapman">M. John Chapman</name>
</region>
<name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Ginsberg, Henry N" sort="Ginsberg, Henry N" uniqKey="Ginsberg H" first="Henry N." last="Ginsberg">Henry N. Ginsberg</name>
</noRegion>
<name sortKey="Fisher, Edward" sort="Fisher, Edward" uniqKey="Fisher E" first="Edward" last="Fisher">Edward Fisher</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Andreotti, Felicita" sort="Andreotti, Felicita" uniqKey="Andreotti F" first="Felicita" last="Andreotti">Felicita Andreotti</name>
</region>
<name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L." last="Catapano">Alberico L. Catapano</name>
</country>
<country name="Suède"><noRegion><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Boren">Jan Boren</name>
</noRegion>
</country>
<country name="Belgique"><noRegion><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S." last="Descamps">Olivier S. Descamps</name>
</noRegion>
</country>
<country name="Finlande"><noRegion><name sortKey="Kovanen, Petri T" sort="Kovanen, Petri T" uniqKey="Kovanen P" first="Petri T." last="Kovanen">Petri T. Kovanen</name>
</noRegion>
<name sortKey="Taskinen, Marja Riitta" sort="Taskinen, Marja Riitta" uniqKey="Taskinen M" first="Marja-Riitta" last="Taskinen">Marja-Riitta Taskinen</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Albert Kuivenhoven, Jan" sort="Albert Kuivenhoven, Jan" uniqKey="Albert Kuivenhoven J" first="Jan" last="Albert Kuivenhoven">Jan Albert Kuivenhoven</name>
</region>
</country>
<country name="Espagne"><noRegion><name sortKey="Masana, Luis" sort="Masana, Luis" uniqKey="Masana L" first="Luis" last="Masana">Luis Masana</name>
</noRegion>
</country>
<country name="Danemark"><noRegion><name sortKey="Nordestgaard, Borge G" sort="Nordestgaard, Borge G" uniqKey="Nordestgaard B" first="Borge G." last="Nordestgaard">Borge G. Nordestgaard</name>
</noRegion>
<name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K." last="Ray">Kausik K. Ray</name>
</region>
</country>
<country name="Croatie"><noRegion><name sortKey="Reiner, Zeljko" sort="Reiner, Zeljko" uniqKey="Reiner Z" first="Zeljko" last="Reiner">Zeljko Reiner</name>
</noRegion>
</country>
<country name="Turquie"><noRegion><name sortKey="Tokgozoglu, Lale" sort="Tokgozoglu, Lale" uniqKey="Tokgozoglu L" first="Lale" last="Tokgözoglu">Lale Tokgözoglu</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F." last="Watts">Gerald F. Watts</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

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